Pre-Conference Workshop Day

October 30, 2023

9:00 – 12:00 am
Workshop A

Exploring the Analytical Tools of Epigenetics for Application in CRISPR Technology

  • Howard Wu Co-Founder & Chief Scientific Officer, Full Circles Therapeutics

Synopsis

The application of epigenetics is revolutionizing our perception on gene expression, with the additional qualities of reversibility and plasticity with transgenerational potential. Join us in paving the way for future analytical interventions, exploring the relationship between CRISPR and epigenetic analytical development.

Attend this workshop to learn about:

  • Leveraging the applications of epigenetics in regulating CRISPR-based therapies
  • Exploring the analytical methods used to analyze variable chromatin accessibility
  • Reviewing the analytical tools for histone modification and computational analysis
  • Comparing gene silencing analytics versus Cas9 analytics; what could future bioinformatics look like?
  • Analyzing enzyme selection and the implication on the analytics used in gene silencing technology
  • Leveraging the applications of epigenetics in regulating CRISPR-based therapies
  • An overview of targeted epigenetic editing technology
  • Case studies using epigenetic editing for targeted gene modulation
  • Therapeutic landscape of epigenetic editing and future perspective

1:00 – 3:00 pm
Workshop B

Exploring the Analytics Utilized in Model Systems: The Correlations From In Vitro to In Vivo

  • Jessica Seitzer Vice President, Genomic Operations, Intellia Therapeutics

Synopsis

This workshop engages with the analytical challenges facing the industry in conducting in vivo experiments. Our objective is to help validate result and overcome costly analytical complications by aligning in vitro and in vivo gene editing through the evaluation of current model systems.

Attend this workshop to learn about:

  • A comprehensive understanding & comparison on the in vitro and in vivo analytical tools
  • Addressing the analytical challenges of validating in vivo results
  • Mouse to Monkey: discussing the innovations in model systems and the analytical pathway
  • Exploring current in vivo model strategies and clarifying the challenges facing in vivo delivery
  • Harnessing artificial intelligence in model development
  • Exploring the analytics and model systems utilized to support in vivo gene editing therapies through FIH trial applications
  • A comprehensive understanding and comparison on the in vitro and in vivo analytical tools in support of FIH Trial applications
  • Orthogonal techniques used to characterize mutagenicity and large-scale chromosomal integrity
  • Exploring current in vivo model strategies and challenges facing in vivo gene editing therapies trial application